GENERIC NAME: SULFAMETHOXAZOLE (sul-fa-meth-OX-a-zole) and TRIMETHOPRIM (trye-METH-oh-prim)
COMMON USES: This medicine is an antibiotic combination used to treat or prevent infections.
BEFORE USING THIS MEDICINE: Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. DO NOT TAKE THIS MEDICINE if you are taking dofetilide or if you will be receiving a live oral typhoid vaccine. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking leucovorin, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), diuretics (eg, hydrochlorothiazide), anticoagulants (eg, warfarin), digoxin, methotrexate, phenytoin, sulfones (eg, dapsone), sulfonylureas (eg, glipizide), or cyclosporine. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including liver or kidney problems, blood problems (eg, anemia, porphyria), asthma, HIV infection, allergies, pregnancy, or breast-feeding. Tell your doctor if you have glucose-6-phosphate dehydrogenase deficiency, an enzyme deficiency, or if you at risk for low levels of folate in the blood (eg, you have alcoholism, you are elderly, you do not absorb nutrients from food properly, you are in a poor nutritional state, you are taking medicine for seizures). USE OF THIS MEDICINE IS NOT RECOMMENDED it you have anemia caused by low levels of folate in the blood, urinary blockage, or if you are in week 38 of pregnancy or later (full-term) or breast-feeding. Use of this medicine in children younger than 2 months old is not recommended; safety and effectiveness in these children have not been confirmed. Discuss with your doctor the risks and benefits of giving this medicine to your child. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
HOW TO USE THIS MEDICINE: Follow the directions for using this medicine provided by your doctor. THIS MEDICINE MAY BE TAKEN WITH FOOD if it upsets your stomach. TAKE THIS MEDICINE with a glass (8 ounces) of water. Drink several additional glasses of water daily unless otherwise directed by your doctor. STORE THIS MEDICINE at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), away from heat, moisture, and light. Keep in a tight, light-resistant container. KEEP THIS MEDICINE out of the reach of children and away from pets. THIS MEDICINE WORKS BEST if it is taken at the same time each day. TO CLEAR UP YOUR INFECTION COMPLETELY, continue taking this medicine for the full course of treatment even if you feel better in a few days. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the Bactrim DS, Gantrisin, glyburide, or probenecid), contact your doctor or pharmacist before taking this medicine. A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness. If you have a question about whether you are allergic to this medicine or if a certain medicine is a sulfonamide, contact your doctor or pharmacist. IF YOU EXPERIENCE difficulty breathing, tightness of chest, swelling of eyelids, face, or lips, or if you develop a rash or hives, tell your doctor immediately. Do not take any more of this medicine unless your doctor tells you to do so. LABORATORY AND/OR MEDICAL TESTS, including complete blood cell counts and kidney function tests, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. THIS MEDICINE MAY AFFECT CERTAIN LAB TEST RESULTS. Make sure laboratory personnel and your doctors know you use this medicine. THIS MEDICINE MAY CAUSE increased sensitivity to the sun. Avoid exposure to the sun or sunlamps until you know how you react to this medicine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. MILD DIARRHEA IS COMMON with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. CONTACT YOUR DOCTOR RIGHT AWAY IF stomach pain or cramps, severe diarrhea, or bloody stools occur. DO NOT treat diarrhea without first checking with your doctor. BE SURE TO USE THIS MEDICINE for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. THIS MEDICINE ONLY WORKS AGAINST BACTERIA; it does not treat viral infections (eg, the common cold). LONG-TERM OR REPEATED USE of this medicine may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of this medicine. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. DO NOT USE THIS MEDICINE if you are in week 38 of pregnancy or later (full-term). THIS MEDICINE IS EXCRETED IN BREAST MILK.DO NOT BREAST_FEED while taking this medicine. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetic medicine.
POSSIBLE SIDE EFFECT: SIDE EFFECTS that may occur while taking this medicine include appetite loss, diarrhea, nausea, or vomiting. If they continue or are bothersome, check with your doctor. CONTACT YOUR DOCTOR IMMEDIATELY if you experience blistered, peeling, red, or swollen skin, bloody or black, tarry stools, chest pain, confusion, dark urine, decreased urination, depression, hallucinations, fever, chills, or sore throat, irregular heartbeat, joint or muscle pain, mental or mood changes, painful or stiff neck, purple patches under the skin, seizures, severe diarrhea, severe or persistent cough, severe or persistent headache, severe or persistent nausea or vomiting, shortness of breath, stomach cramps/pain, unusual bruising or bleeding, unusual tiredness or weakness, unusually pale skin, vaginal irritation or discharge, or yellowing of the skin or eyes. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, hive, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue, or unusual hoarseness. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include blood in urine, confusion, depression, dizziness, drowsiness, loss of consciousness, severe nausea or vomiting, severe or prolonged headache, or unusual bruising or bleeding.
ADDITIONAL INFORMATION: DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.
The information in this monograph is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This information is generalized and is not intended as specific medical advice. If you have questions about the medicines you are taking or would like more information, check with your doctor, pharmacist, or nurse.
Copyright 2011 Wolters Kluwer Health, Inc. All rights reserved.